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Article

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002

Chai Yaohui, Shao Jianqiang, Miller Victor M, Williams Aislinn, Paulson Henry L

Abstract excerpt

Protein misfolding and aggregation are central features of the polyglutamine neurodegenerative disorders, but the dynamic properties of expanded polyglutamine proteins are poorly understood. Here, we use fluorescence recovery after photobleaching (FRAP) and fluorescence loss in photobleaching (FLIP) with green fluorescent protein fusion proteins to study polyglutamine protein kinetics in living cells. Our results...

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Identifiers

PMID: 12084819
DOI: 10.1073/pnas.152101299
PMCID: PMC123137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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