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Article

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo.

Neurobiology of disease - 1 Dec 2020

Otte Charlton G, Fortuna Tyler R, Mann Jacob R, Gleixner Amanda M, Ramesh Nandini, Pyles Noah J, Pandey Udai B, Donnelly Christopher J

Abstract excerpt

TDP-43 is a predominantly nuclear DNA/RNA binding protein that is often mislocalized into insoluble cytoplasmic inclusions in post-mortem patient tissue in a variety of neurodegenerative disorders including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD). The underlying causes of TDP-43 proteinopathies remain unclear, but recent studies indicate the formation of these protein assemblies is...

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Identifiers

PMID: 32927062
DOI: 10.1016/j.nbd.2020.105078
PMCID: PMC9040199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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