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Article

Crk and CrkL as Therapeutic Targets for Cancer Treatment

27 Mar 2021

Abstract excerpt

Crk and CrkL are cellular counterparts of the viral oncoprotein v-Crk. Crk and CrkL are overexpressed in many types of human cancer, correlating with poor prognosis. Furthermore, gene knockdown and knockout of Crk and CrkL in tumor cell lines suppress tumor cell functions, including cell proliferation, transformation, migration, invasion, epithelial-mesenchymal transition, resistance to chemotherapy drugs, and in...

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PMID: 33801580
DOI: 10.3390/cells10040739

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