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Models of Crk Adaptor Proteins in Cancer

1 May 2012

Abstract excerpt

The Crk family of adaptor proteins (CrkI, CrkII, and CrkL), originally discovered as the oncogene fusion product, v-Crk, of the CT10 chicken retrovirus, lacks catalytic activity but engages with multiple signaling pathways through their SH2 and SH3 domains. Crk proteins link upstream tyrosine kinase and integrin-dependent signals to downstream effectors, acting as adaptors in diverse signaling pathways and...

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PMID: 23226572
DOI: 10.1177/1947601912459951

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