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Article

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma.

Oncotarget - 10 Nov 2015

Kumar Sushil, Lu Bin, Dixit Updesh, Hossain Sajjad, Liu Yongzhang, Li Jing, Hornbeck Peter, Zheng Weiming, Sowalsky Adam G, Kotula Leszek, Birge Raymond B

Abstract excerpt

Crk is the prototypical member of a class of Src homology 2 (SH2) and Src homology 3 (SH3) domain-containing adaptor proteins that positively regulate cell motility via the activation of Rac1 and, in certain tumor types such as GBM, can promote cell invasion and metastasis by mechanisms that are not well understood. Here we demonstrate that Crk, via its phosphorylation at Tyr251, promotes invasive behavior of...

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Identifiers

PMID: 26473374
DOI: 10.18632/oncotarget.6096
PMCID: PMC4741966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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