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Article

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

27 May 2019

Abstract excerpt

BACKGROUND: Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked to leukemia via its binding partners BCR-ABL and TEL-ABL, upregulated in multiple types of...

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PMID: 31133010
DOI: 10.1186/s12885-019-5671-8

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