Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.

Mechanisms of ageing and development - 1 Jun 2021

Yashin Anatoliy I, Wu Deqing, Arbeev Konstantin, Bagley Olivia, Akushevich Igor, Duan Matt, Yashkin Arseniy, Ukraintseva Svetlana

Abstract excerpt

Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possibility that these genes may influence AD non-linearly, through interactions of their products. In this paper, we selected two stress-related genes (GCN2/EIF2AK4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Protein Serine-Threonine Kinases

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33798591
DOI: 10.1016/j.mad.2021.111477
PMCID: PMC8173104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.PMID 33798591Read ↗

Shared Genetic Etiology between Alzheimer's Disease and Blood Levels of Specific Cytokines and Growth Factors.Semantic proximity Read ↗

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease.Semantic proximity Read ↗

Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A lociSemantic proximity Read ↗

Modeling genotype-protein interaction and correlation for Alzheimer's disease: a multi-omics imaging genetics study.Semantic proximity Read ↗

Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci.Semantic proximity Read ↗

Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.Semantic proximity Read ↗

Hidden risk genes with high-order intragenic epistasis in Alzheimer's disease.Semantic proximity Read ↗

Synergistic interaction between APOE and family history of Alzheimer's disease on cerebral amyloid deposition and glucose metabolism.Semantic proximity Read ↗

Pleiotropic Associations with Alzheimer's Disease and Physical Activity: Sex Differences and the Effects of Environment.Semantic proximity Read ↗

Psychosocial Hierarchies of Modifiable Risk for Alzheimer’s Disease: A Networks AnalysisSemantic proximity Read ↗

Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42.Semantic proximity Read ↗

ApoE Modifier Alleles for Alzheimer's Disease Discovered by Information Theory Dependency Measures: MIST Software Package.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.