Article
Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.
American journal of human genetics - 6 Apr 2012
Raj Towfique, Shulman Joshua M, Keenan Brendan T, Chibnik Lori B, Evans Denis A, Bennett David A, Stranger Barbara E, De Jager Philip L
Abstract excerpt
Recent genome-wide association studies have identified a number of susceptibility loci for Alzheimer disease (AD). To understand the functional consequences and potential interactions of the associated loci, we explored large-scale data sets interrogating the human genome for evidence of positive natural selection. Our findings provide significant evidence for signatures of recent positive selection acting on...
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