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Article

Phosphorylated human galectin-3: facile large-scale preparation of active lectin and detection of structural changes by CD spectroscopy.

Biochimica et biophysica acta - 1 Apr 2008

Kübler Dieter, Hung Chien-Wen, Dam Tarun K, Kopitz Jürgen, André Sabine, Kaltner Herbert, Lohr Michaela, Manning Joachim C, He Lizhong, Wang Hui, Middelberg Anton, Brewer C Fred, Reed Jennifer, Lehmann Wolf-Dieter, Gabius Hans-Joachim

Abstract excerpt

Galectin-3 has a unique modular design. Its short N-terminal stretch can be phosphorylated, relevant for nuclear export and anti-anoikis/apoptosis activity. Enzymatic modification by casein kinase 1 at constant ATP concentration yielded mg quantities of mono- and diphosphorylated derivatives at Ser5/Ser11 in a 2:1 ratio. Their carbohydrate-inhibitable binding to asialofetuin, cell surfaces of three tumor lines,...

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PMID: 18302943
DOI: 10.1016/j.bbagen.2008.01.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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