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Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer

29 Apr 2025

Abstract excerpt

PURPOSE: The Cancer Genome Atlas (TCGA) project defined four distinct molecular subtypes of esophagogastric adenocarcinoma: microsatellite instable (MSI), Epstein-Barr virus (EBV)-associated, genomically stable (GS), and chromosomally instable (CIN). However, an association between molecular subtypes and clinical outcomes has not been clearly demonstrated. Given few actionable biomarkers, we investigated the...

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PMID: 40299774
DOI: 10.1158/1078-0432.ccr-24-3473

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