Article

Scalable, fast and accurate differential gene expression testing from millions of cells of multiple patients

2025-07-30

Abstract excerpt

Since the development of DNA microarrays and later RNA bulk sequencing, testing with statistically independent samples has been the standard method for detecting genes with different transcription patterns. Single-cell assays challenge these assumptions because individual cells are statistically dependent, and all proposed methodologies present mathematical limitations or computational bottlenecks that prevent a s...

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Identifiers and source

Literature Corpus work: 0598be0a-04a0-50a8-9832-628cb1371dee
DOI: 10.1101/2025.07.24.666556

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