Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer

1 Mar 2021

Abstract excerpt

Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has yet to be explored in the context of HNSCC. Here, we tested the effects of complement inhibition and its therapeutic potential in HNSCC. Methods We conducted our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33789881
DOI: 10.1136/jitc-2021-002585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancerPMID 33789881Read ↗

Local, but not circulating, complement C3 governs immune checkpoint blockade efficacySemantic proximity Read ↗

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis.Semantic proximity Read ↗

Early Neoplastic Progression Is Complement IndependentSemantic proximity Read ↗

A Novel Syngeneic Mouse Model to Study Immune Evasion in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cellsSemantic proximity Read ↗

Complement as a Biological Tool to Control Tumor GrowthSemantic proximity Read ↗

C5aR1 inhibition alleviates cranial radiation-induced cognitive declineSemantic proximity Read ↗

Complement is increased in treatment resistant rectal cancer and modulates radioresistanceSemantic proximity Read ↗

Complement Is a Central Mediator of Radiotherapy-Induced Tumor-Specific Immunity and Clinical ResponseSemantic proximity Read ↗

Specific blockade CD73 alters the "exhausted" phenotype of T cells in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.Semantic proximity Read ↗

Promotion of an Antitumor Immune Program by a Tumor Specific Complement Activating AutoantibodySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.