Article

Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cells

2024-08-02

Abstract excerpt

Immune-surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell-mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a novel function for intracellular C3d, we discovered that C3d...

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Literature Corpus work: c3b1dcd2-01a8-545a-b80b-882da76de401
DOI: 10.1101/2024.07.31.606044

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