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Article

Variability of CYP2C8 Polymorphisms in Three Jordanian Populations: Circassians, Chechens and Jordanian-Arabs.

Journal of immigrant and minority health - 1 Oct 2022

Abudahab Sara, Hakooz Nancy, Tobeh Nuha, Gogazeh Esraa, Gharaibeh Munir, Al-Eitan Laith, Zihlif Malek, Dajani Rana

Abstract excerpt

CYP2C8 is a member of Cytochrome P450 enzymes system. It plays an important role in metabolizing a wide range of exogenous and endogenous compounds. CYP2C8 is involved in the metabolism of more than 100 drugs, typical substrates include: anticancer agents, antidiabetic agents, antimalarial agents, lipid lowering drugs and many others that constitute 20% of clinically prescribed drugs. Genetic variations of CYP2C8...

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PMID: 34448113
DOI: 10.1007/s10903-021-01264-x

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