Article
Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for pharmacogenetics.
Medicine - 23 Jul 2021
Kassogue Yaya, Diakite Brehima, Kassogue Oumar, Konate Issa, Tamboura Kadidiatou, Diarra Zoumana, Maiga Mamoudou, Dehbi Hind, Nadifi Sellama, Traore Cheick Bougadari, Kamate Bakarou, Dao Sounkalo, Doumbia Seydou, Dolo Guimogo
Abstract excerpt
ABSTRACT: Cytochrome P450 enzymes play a central role in the phase I biotransformation process of a wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is noteworthy that these enzymes are highly polymorphic and, depending on the genetic makeup, an individual may have impaired enzymatic activity. Therefore, the identification of genetic variants in these genes could facilitate the...
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