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Article

Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design.

Scientific reports - 30 Mar 2021

Castro João, Beviano Vanessa, Paço Ana, Leitão-Castro Joana, Cadete Francisco, Francisco Miguel, Freitas Renata

Abstract excerpt

The overexpression of hoxd13a during zebrafish fin development causes distal endochondral expansion and simultaneous reduction of the finfold, mimicking the major events thought to have happened during the fin-to-limb transition in Vertebrates. We investigated the effect of hoxd13a overexpression on putative downstream targets and found it to cause downregulation of proximal fin identity markers (meis1 and emx2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33785799
DOI: 10.1038/s41598-021-86621-4
PMCID: PMC8009906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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