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Article

The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development.

Scientific reports - 9 Oct 2024

Ishizaka Mizuki, Maeno Akiteru, Nakazawa Hidemichi, Fujii Renka, Oikawa Sae, Tani Taisei, Kanno Haruna, Koita Rina, Kawamura Akinori

Abstract excerpt

The paralogs 9-13 Hox genes in mouse HoxA and HoxD clusters are critical for limb development. When both HoxA and HoxD clusters are deleted in mice, significant limb truncation is observed compared to the phenotypes of single and compound mutants of Hox9-13 genes in these clusters. In zebrafish, mutations in hox13 genes in HoxA- and HoxD-related clusters result in abnormal morphology of pectoral fins, homologous...

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PMID: 39384796
DOI: 10.1038/s41598-024-74134-9
PMCID: PMC11464670

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