Article
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.
mBio - 30 Mar 2021
Zhang Peng, Kwon Alice L, Guzzo Christina, Liu Qingbo, Schmeisser Hana, Miao Huiyi, Lin Yin, Cimbro Raffaello, Huang Jinghe, Connors Mark, Schmidt Stephen D, Dolan Michael A, Armstrong Anthony A, Lusso Paolo
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) envelope trimer maintains a closed, metastable configuration to protect vulnerable epitopes from neutralizing antibodies. Here, we identify key hydrophobic constraints at the trimer apex that function as global stabilizers of the HIV-1 envelope spike configuration. Mutation of individual residues within four hydrophobic clusters that fasten together the V1V2, V3,...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Antibodies, Neutralizing
- HIV Antibodies
- HIV Infections
- HIV-1
- Humans
- Hydrophobic and Hydrophilic Interactions
- Mutation
- env Gene Products, Human Immunodeficiency Virus