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Article

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.

Nature communications - 24 Jan 2020

Henderson Rory, Lu Maolin, Zhou Ye, Mu Zekun, Parks Robert, Han Qifeng, Hsu Allen L, Carter Elizabeth, Blanchard Scott C, Edwards R J, Wiehe Kevin, Saunders Kevin O, Borgnia Mario J, Bartesaghi Alberto, Mothes Walther, Haynes Barton F, Acharya Priyamvada, Munir Alam S

Abstract excerpt

The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of conformational transitions, with allosteric elements in each protomer orchestrating host receptor-induced exposure of the co-receptor binding site and fusion elements. To understand the molecular details of this allostery, here, we introduce Env mutations aimed to prevent CD4-induced rearrangements in the HIV-1 BG505 Env...

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Share to Allosteric Regulation
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to Mutant Proteins

Share to Protein Domains

Share to Protein Multimerization

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Source

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Identifiers

PMID: 31980614
DOI: 10.1038/s41467-019-14196-w
PMCID: PMC6981184

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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