Article
A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target.
Viruses - 5 Sept 2021
Parker Miller Emma, Finkelstein Maxwell T, Erdman Molly C, Seth Paul C, Fera Daniela
Abstract excerpt
Antibodies that can neutralize diverse HIV-1 strains develop in ~10-20% of HIV-1 infected individuals, and their elicitation is a goal of vaccine design. Such antibodies can also serve as therapeutics for those who have already been infected with the virus. Structural characterizations of broadly reactive antibodies in complex with the HIV-1 spike indicate that there are a limited number of sites of vulnerability...
Topics
- AIDS Vaccines
- Animals
- Antibodies, Neutralizing
- Binding Sites
- CD4 Antigens
- Epitopes
- HIV Antibodies
- HIV Infections
- HIV-1
- Humans
- Mice
- Mutation