Article
Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia.
British journal of cancer - 1 May 2021
Kane Alexandra M, Liu Cheng, Fennell Lochlan J, McKeone Diane M, Bond Catherine E, Pollock Pamela M, Young Graeme, Leggett Barbara A, Whitehall Vicki L J
Abstract excerpt
BACKGROUND: Aspirin reduces the incidence of conventional adenomas driven by APC mutation and thus colorectal cancer. The effect of aspirin on the ~20% of colorectal cancers arising via BRAF mutation is yet to be established. METHODS: BrafV637E/+;Villin-CreERT2/+ mice were allocated to a control (n = 86) or aspirin-supplemented (n = 83) diet. After 14 months the incidence of murine serrated lesions, carcinoma and...
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