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Article

Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target.

Nature reviews. Cardiology - 1 Nov 2025

Schuermans Art, Honigberg Michael C

Abstract excerpt

Clonal haematopoiesis is the clonal expansion of blood stem cells with acquired mutations. Clonal haematopoiesis of indeterminate potential (CHIP), traditionally defined as clonal haematopoiesis driven by a pre-leukaemic mutation in at least 2% of sequenced alleles, affects 10-20% of individuals aged >70 years. Although CHIP is considered a precursor condition for haematological malignancies, population-based...

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Identifiers

PMID: 40175709
DOI: 10.1038/s41569-025-01148-9
PMCID: PMC12353217

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