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Article

Growth Hormone Receptor Antagonists: Discovery, Development, and Use in Patients with Acromegaly

1 Oct 2002

Abstract excerpt

An understanding of the events that occur during GH receptor (GHR) signaling has facilitated the development of a GHR antagonist (pegvisomant) for use in humans. This molecule has been designed to compete with native GH for the GHR and to prevent its proper or functional dimerization-a process that is critical for GH signal transduction and IGF-I synthesis and secretion. Clinical trials in patients with...

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Identifiers

PMID: 12372843
DOI: 10.1210/er.2001-0022

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