Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies?

doi:10.1085/jgp.202613981

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Article

Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies?

The Journal of general physiology - 6 Jul 2026

Striessnig Jörg

Abstract excerpt

Calmodulin (CaM) serves as one of the key cellular Ca2+ sensors with >300 targets and a highly conserved structure since its appearance in early eukaryogenesis. Three distinct CaM genes (CALM1, CALM2, and CALM3) encode one identical CaM protein in mammals. This low tolerance for structural changes highlights that CaM mutations are likely not well tolerated and therefore cause disease in humans. The first...

Topics

Calmodulin
Humans
Animals
Brain
Ryanodine Receptor Calcium Release Channel
Calcium Channels, L-Type
Calcium Channels
Mutation

Source

Open in PubMed

Identifiers

PMID: 42126403
DOI: 10.1085/jgp.202613981

Genes

CALM1
CALM2
CALM3
RYR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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