Essential thrombocythaemia with mutation in MPL: clinicopathological correlation and comparison with JAK2V617F-mutated and CALR-mutated genotypes.

doi:10.1136/jclinpath-2018-205227

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Article

Essential thrombocythaemia with mutation in MPL: clinicopathological correlation and comparison with JAK2V617F-mutated and CALR-mutated genotypes.

Journal of clinical pathology - 1 Nov 2018

Alvarez-Larran Alberto, Martínez Daniel, Arenillas Leonor, Rubio Ariadna, Arellano-Rodrigo Eduardo, Hernández Boluda Juan Carlos, Papaleo Natalia, Caballero Gonzalo, Martínez Clara, Ferrer-Marín Francisca, Mata María Isabel, Pérez-Encinas Manuel, Durán María Antonia, Alonso José María, Carreño-Tarragona Gonzalo, Alonso Juan Manuel, Noya Soledad, Magro Elena, Pérez Raúl, López-Guerra Mónica, Pastor-Galán Irene, Cervantes Francisco, Besses Carlos, Colomo Luis, Rozman María

Abstract excerpt

AIM: To characterise the clinical and histological features of MPL-mutated essential thrombocythaemia (ET). PATIENTS AND METHODS: Bone marrow biopsies of 175 patients with ET were centrally reviewed according to the 2016 WHO classification, including 42 cases with MPL mutation, 98 JAK2V617F-mutated and 35 CALR-mutated. Clinical and histological features were compared among the three genotypes included in the...

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PMID: 29934356
DOI: 10.1136/jclinpath-2018-205227

Genes

MPL
CALR

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