Article
PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane.
Cell calcium - 1 Jun 2006
Penna Aubin, Juvin Véronique, Chemin Jean, Compan Vincent, Monet Michael, Rassendren François-A
Abstract excerpt
Cellular or chemical activators for most transient receptor potential channels of the vanilloid subfamily (TRPV) have been identified in recent years. A remarkable exception to this is TRPV2, for which cellular events leading to channel activation are still a matter of debate. Diverse stimuli such as extreme heat or phosphatidylinositol-3 kinase (PI3-kinase) regulated membrane insertion have been shown to promote...
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