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Article

Neuropathologic variants of sporadic Creutzfeldt-Jakob disease and codon 129 of PrP gene.

Neurology - 25 Apr 2000

Hauw J J, Sazdovitch V, Laplanche J L, Peoc'h K, Kopp N, Kemeny J, Privat N, Delasnerie-Lauprêtre N, Brandel J P, Deslys J P, Dormont D, Alpérovitch A

Abstract excerpt

OBJECTIVES: To determine the contribution of methionine/valine (Met/Val) polymorphism at codon 129 of the prion protein (PrP) gene in the neuropathologic pattern and mechanisms of lesion development in sporadic Creutzfeldt-Jakob disease. BACKGROUND: Creutzfeldt-Jakob disease is a transmissible spongiform encephalopathy characterized by a conformational change of PrP and a variety of PrP deposits in the brain,...

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Identifiers

PMID: 10762506
DOI: 10.1212/wnl.54.8.1641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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