Article
Prion Strain Characterization of a Novel Subtype of Creutzfeldt-Jakob Disease.
Journal of virology - 1 Jun 2017
Galeno Roberta, Di Bari Michele Angelo, Nonno Romolo, Cardone Franco, Sbriccoli Marco, Graziano Silvia, Ingrosso Loredana, Fiorini Michele, Valanzano Angelina, Pasini Giulia, Poleggi Anna, Vinci Ramona, Ladogana Anna, Puopolo Maria, Monaco Salvatore, Agrimi Umberto, Zanusso Gianluigi, Pocchiari Maurizio
Abstract excerpt
In 2007, we reported a patient with an atypical form of Creutzfeldt-Jakob disease (CJD) heterozygous for methionine-valine (MV) at codon 129 who showed a novel pathological prion protein (PrPTSE) conformation with an atypical glycoform (AG) profile and intraneuronal PrP deposition. In the present study, we further characterize the conformational properties of this pathological prion protein (PrPTSE MVAG), showing...
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