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Article

Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain.

The Journal of biological chemistry - 12 Oct 2007

Kobayashi Atsushi, Asano Masahiro, Mohri Shirou, Kitamoto Tetsuyuki

Abstract excerpt

The genotype (methionine or valine) at polymorphic codon 129 of the human prion protein (PrP) gene and the type (type 1 or type 2) of abnormal isoform of PrP (PrP(Sc)) are major determinants of the clinicopathological phenotypes of sporadic Creutzfeldt-Jakob disease (sCJD). Here we found that the...

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PMID: 17709374
DOI: 10.1074/jbc.M704597200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17709374-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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