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Article

Characterization of variant Creutzfeldt-Jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes.

The Journal of biological chemistry - 26 Jul 2013

Takeuchi Atsuko, Kobayashi Atsushi, Ironside James W, Mohri Shirou, Kitamoto Tetsuyuki

Abstract excerpt

To date, all clinical variant Creutzfeldt-Jakob disease (vCJD) patients are homozygous for methionine at polymorphic codon 129 (129M/M) of the prion protein (PrP) gene. However, the appearance of asymptomatic secondary vCJD infection in individuals with a PRNP codon 129 genotype other than M/M and transmission studies using animal models have raised the concern that all humans might be susceptible to vCJD prions,...

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Identifiers

PMID: 23792955
DOI: 10.1074/jbc.M113.470328
PMCID: PMC3724625

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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