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Article

Hypermutated tumours across 11 cancer types show three distinct immune subtypes.

European journal of cancer (Oxford, England : 1990) - 1 May 2021

Hu Wangxiong, Chen Jiani, Qi Lina, Ge Weiting, Zheng Shu, Yang Yanmei

Abstract excerpt

BACKGROUND: Complete remission is observed in less than half of hypermutated (HM) tumours after immune checkpoint blockade therapy, indicating that HM tumours are very heterogeneous. Thus, there is an urgent requirement to decipher the unknown intrinsic HM tumour subtypes. METHODS: Statistical analysis was performed on somatic mutation data from 5519 tumours across 11 cancer types obtained from The Cancer Genome...

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PMID: 33752133
DOI: 10.1016/j.ejca.2021.01.044

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