Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer.

Journal of cellular and molecular medicine - 1 Apr 2021

Liu Zaoqu, Wang Libo, Guo Chunguang, Liu Long, Jiao Dechao, Sun Zhenqiang, Wu Kunpeng, Zhao Yanan, Han Xinwei

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide. Although treatment strategies for solid tumours have been revolutionized by immunotherapy, only a small subset of CRC patients benefit. Using two-independent cohorts, we found the common frequently mutated genes TTN and OBSCN had the significant correlation with higher tumour mutation burden (TMB) and favourable overall survival....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connectin

Share to DNA Polymerase II

Share to Immune Checkpoint Inhibitors

Share to Poly-ADP-Ribose Binding Proteins

Share to Protein Serine-Threonine Kinases

Share to Rho Guanine Nucleotide Exchange Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33624434
DOI: 10.1111/jcmm.16393
PMCID: PMC8034451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer.PMID 33624434Read ↗

Comprehensive analysis reveals the molecular heterogeneity and the differences in prognosis and immunotherapy sensitivity in hypermutated colorectal cancer.Semantic proximity Read ↗

Immune Landscape Refines the Classification of Colorectal Cancer With Heterogeneous Prognosis, Tumor Microenvironment and Distinct Sensitivity to Frontline TherapiesSemantic proximity Read ↗

AI-Driven Prediction Unveils SMAD4-Specific HLA-Restricted Epitopes: A Novel Therapeutic Target for Precision Treatment of Peritoneal Metastasis in Colorectal CancerSemantic proximity Read ↗

Conventional therapy induces tumor immunoediting and modulates the immune contexture in colorectal cancerSemantic proximity Read ↗

T-Cell Infiltration and Clonality May Identify Distinct Survival Groups in Colorectal Cancer: Development and Validation of a Prognostic Model Based on The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC)Semantic proximity Read ↗

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysisSemantic proximity Read ↗

Colorectal medullary carcinoma: a pathological subtype with intense immune response and potential to benefit from immune checkpoint inhibitors.Semantic proximity Read ↗

Unveiling the Prognostic Significance and Immunological Characteristics of T Cell Marked Ubiquitination Related Genes in Colorectal Adenocarcinoma via Single-Cell and bulk RNA SequencingSemantic proximity Read ↗

Constructing prognostic models for colorectal cancer through dynamic profiling of tumor-associated neutrophils via single-cell and bulk RNA sequencingSemantic proximity Read ↗

OBSCN as biomarker for evaluating tumor mutation burden and anti-tumor immunity in Stomach adenocarcinomaSemantic proximity Read ↗

COADREADx: A comprehensive algorithmic dissection unravels salient biomarkers and actionable insights into the discrete progression of colorectal cancerSemantic proximity Read ↗

Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.