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Article

Comprehensive analysis reveals the molecular heterogeneity and the differences in prognosis and immunotherapy sensitivity in hypermutated colorectal cancer.

Medicine - 9 Jan 2026

Bai Gaobo, Yang Xiaojun, Xiao Liang, Xiong Chunhui

Abstract excerpt

This study aimed to investigate the molecular heterogeneity, accurately evaluate the prognosis, and identify those patients who would benefit most from immunotherapy in the hypermutated colorectal cancer (CRC) cohort. The unsupervised clustering analysis of CRC somatic mutation data from the Cancer Genome Atlas database was performed by combining tumor mutational burden (TMB) and indel burden to identify the...

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Identifiers

PMID: 41517671
DOI: 10.1097/MD.0000000000047073
PMCID: PMC12795009

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CTLA4
POLE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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