Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring a Local Genetic Interaction Network Using Evolutionary Replay Experiments.

Molecular biology and evolution - 29 Jul 2021

Vignogna Ryan C, Buskirk Sean W, Lang Gregory I

Abstract excerpt

Understanding how genes interact is a central challenge in biology. Experimental evolution provides a useful, but underutilized, tool for identifying genetic interactions, particularly those that involve non-loss-of-function mutations or mutations in essential genes. We previously identified a strong positive genetic interaction between specific mutations in KEL1 (P344T) and HSL7 (A695fs) that arose in an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Gene Regulatory Networks
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 33749796
DOI: 10.1093/molbev/msab087
PMCID: PMC8321538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring a Local Genetic Interaction Network Using Evolutionary Replay Experiments.PMID 33749796Read ↗

Experimental evolution of the model eukaryote Saccharomyces cerevisiae yields insight into the molecular mechanisms underlying adaptation.Semantic proximity Read ↗

Extremely Rare Polymorphisms in Saccharomyces cerevisiae Allow Inference of the Mutational Spectrum.Semantic proximity Read ↗

A stress response that allows highly mutated eukaryotic cells to survive and proliferateSemantic proximity Read ↗

Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast.Semantic proximity Read ↗

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.Semantic proximity Read ↗

High-resolution mutation mapping reveals parallel experimental evolution in yeast.Semantic proximity Read ↗

High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations.Semantic proximity Read ↗

Environmental robustness of the global yeast genetic interaction network.Semantic proximity Read ↗

Experimental Evolution and Resequencing Analysis of Yeast.Semantic proximity Read ↗

The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast.Semantic proximity Read ↗

Insights into molecular evolution from yeast genomics.Semantic proximity Read ↗

Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.