Article
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.
eLife - 19 Jan 2021
Johnson Milo S, Gopalakrishnan Shreyas, Goyal Juhee, Dillingham Megan E, Bakerlee Christopher W, Humphrey Parris T, Jagdish Tanush, Jerison Elizabeth R, Kosheleva Katya, Lawrence Katherine R, Min Jiseon, Moulana Alief, Phillips Angela M, Piper Julia C, Purkanti Ramya, Rego-Costa Artur, McDonald Michael J, Nguyen Ba Alex N, Desai Michael M
Abstract excerpt
Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205 Saccharomyces cerevisiae populations (124 haploid and 81 diploid) for ~10,000,000 generations in three environments. We measured the dynamics of fitness changes over time, finding repeatable patterns of declining adaptability. Sequencing revealed...
Topics
- Adaptation, Biological
- Diploidy
- Evolution, Molecular
- Mutation
- Mutation Rate
- Phenotype
- Saccharomyces cerevisiae