Article
Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility.
American journal of epidemiology - 1 Feb 2017
Gianfrancesco Milena A, Glymour M Maria, Walter Stefan, Rhead Brooke, Shao Xiaorong, Shen Ling, Quach Hong, Hubbard Alan, Jónsdóttir Ingileif, Stefánsson Kári, Strid Pernilla, Hillert Jan, Hedström Anna, Olsson Tomas, Kockum Ingrid, Schaefer Catherine, Alfredsson Lars, Barcellos Lisa F
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune disease with both genetic and environmental risk factors. Recent studies indicate that childhood and adolescent obesity double the risk of MS, but this association may reflect unmeasured confounders rather than causal effects of obesity. We used separate-sample Mendelian randomization to estimate the causal effect of body mass index (BMI) on susceptibility to MS. Using...
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