Article
The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 2021
Harroud Adil, Manousaki Despoina, Butler-Laporte Guillaume, Mitchell Ruth E, Davey Smith George, Richards J Brent, Baranzini Sergio E
Abstract excerpt
BACKGROUND: Obesity is associated with increased risk of multiple sclerosis (MS); however, the underlying mechanisms remain unclear. OBJECTIVE: To determine the extent to which decreased vitamin D bioavailability and altered levels of adiponectin and leptin mediate the association between obesity and MS. METHODS: We performed Mendelian randomization (MR) analyses to estimate the effects on MS of body mass index...
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