[The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior].

doi:10.7868/S002689841704005X

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Article

[The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior].

Molekuliarnaia biologiia - 1 Jan 2000

Bazovkina D V, Kondaurova E M, Tsybko A S, Kovetskaya A I, Ilchibaeva T V, Naumenko V S

Abstract excerpt

Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in the brain, while the mature form of BDNF is involved in neurogenesis. It is known that chronic alcoholization leads to the activation of apoptotic processes, neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have studied the...

Topics

Alcoholism
Animals
Brain-Derived Neurotrophic Factor
Depressive Disorder
Disease Models, Animal
Ethanol
Frontal Lobe
Gene Expression Regulation
Genetic Predisposition to Disease
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred CBA

Mice, Transgenic

Protein Precursors

Receptor, trkB

Receptors, Nerve Growth Factor

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 28900083
DOI: 10.7868/S002689841704005X

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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