Article
[The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior].
Molekuliarnaia biologiia - 1 Jan 2000
Bazovkina D V, Kondaurova E M, Tsybko A S, Kovetskaya A I, Ilchibaeva T V, Naumenko V S
Abstract excerpt
Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in the brain, while the mature form of BDNF is involved in neurogenesis. It is known that chronic alcoholization leads to the activation of apoptotic processes, neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have studied the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.