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Article

Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens.

Scientific reports - 8 Nov 2016

Zhang Ji-Chun, Yao Wei, Ren Qian, Yang Chun, Dong Chao, Ma Min, Wu Jin, Hashimoto Kenji

Abstract excerpt

The α7 subtype of nicotinic acetylcholine receptor (nAChR) plays a role in the inflammation which is implicated in depression. This study was undertaken to examine the role of α7 nAChR in depression using α7 nAChR knock-out (KO) mice. Serum levels of tumor necrosis factor-α and interlukin-1β in KO mice were higher than wild-type mice, suggesting an inflammatory process in KO mice. α7 nAChR KO mice showed...

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Identifiers

PMID: 27821848
DOI: 10.1038/srep36705
PMCID: PMC5099687

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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