Article
Copy number-dependent DNA methylation of the Pyricularia oryzae MAGGY retrotransposon is triggered by DNA damage.
Communications biology - 19 Mar 2021
Van Vu Ba, Nguyen Quyet, Kondo-Takeoka Yuki, Murata Toshiki, Kadotani Naoki, Thi Nguyen Giang, Arazoe Takayuki, Ohsato Shuichi, Nakayashiki Hitoshi
Abstract excerpt
Transposable elements are common targets for transcriptional and post-transcriptional gene silencing in eukaryotic genomes. However, the molecular mechanisms responsible for sensing such repeated sequences in the genome remain largely unknown. Here, we show that machinery of homologous recombination (HR) and RNA silencing play cooperative roles in copy number-dependent de novo DNA methylation of the...
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