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Article

The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa.

Genes & development - 1 Mar 2010

Honda Shinji, Lewis Zachary A, Huarte Maite, Cho Lucy Y, David Larry L, Shi Yang, Selker Eric U

Abstract excerpt

Transposable elements are common in genomes and must be controlled. Many organisms use DNA methylation to silence such selfish DNA, but the mechanisms that restrict the methylation to appropriate regions are largely unknown. We identified a JmjC domain protein in Neurospora, DNA METHYLATION MODULATOR-1 (DMM-1), that prevents aberrant spreading of DNA and histone H3K9 methylation from inactivated transposons into...

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Identifiers

PMID: 20139222
DOI: 10.1101/gad.1893210
PMCID: PMC2827840

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