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Article

Prioritizing candidate disease genes by network-based boosting of genome-wide association data.

Genome research - 1 Jul 2011

Lee Insuk, Blom U Martin, Wang Peggy I, Shim Jung Eun, Marcotte Edward M

Abstract excerpt

Network "guilt by association" (GBA) is a proven approach for identifying novel disease genes based on the observation that similar mutational phenotypes arise from functionally related genes. In principle, this approach could account even for nonadditive genetic interactions, which underlie the...

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Identifiers

PMID: 21536720
DOI: 10.1101/gr.118992.110
PMCID: PMC3129253

Genes

BACH2
GRB2
SHC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21536720-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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