Article
Using whole-exome sequencing and protein interaction networks to prioritize candidate genes for germline cutaneous melanoma susceptibility.
Scientific reports - 14 Oct 2020
Yepes Sally, Tucker Margaret A, Koka Hela, Xiao Yanzi, Jones Kristine, Vogt Aurelie, Burdette Laurie, Luo Wen, Zhu Bin, Hutchinson Amy, Yeager Meredith, Hicks Belynda, Freedman Neal D, Chanock Stephen J, Goldstein Alisa M, Yang Xiaohong R
Abstract excerpt
Although next-generation sequencing has demonstrated great potential for novel gene discovery, confirming disease-causing genes after initial discovery remains challenging. Here, we applied a network analysis approach to prioritize candidate genes identified from whole-exome sequencing analysis of 98 cutaneous melanoma patients from 27 families. Using a network propagation method, we ranked candidate genes by...
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