DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease.

doi:10.1093/ajcn/nqab016

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Article

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease.

The American journal of clinical nutrition - 1 Jun 2021

Sala-Vila Aleix, Arenaza-Urquijo Eider M, Sánchez-Benavides Gonzalo, Suárez-Calvet Marc, Milà-Alomà Marta, Grau-Rivera Oriol, González-de-Echávarri José M, Crous-Bou Marta, Minguillón Carolina, Fauria Karine, Operto Grégory, Falcón Carles, Salvadó Gemma, Cacciaglia Raffaele, Ingala Silvia, Barkhof Frederik, Schröder Helmut, Scarmeas Nikolaos, Gispert Juan-Domingo, Molinuevo José L

Abstract excerpt

BACKGROUND: The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (22:6n-3) before the onset of AD symptoms, particularly in APOE-ε4 carriers. Brain alterations in the preclinical stage can be detected by structural MRI. OBJECTIVES: We aimed, in middle-aged cognitively unimpaired individuals at increased...

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PMID: 33733657
DOI: 10.1093/ajcn/nqab016
PMCID: PMC8168359

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