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Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress

17 Mar 2021

Abstract excerpt

Once disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition of DTCs in a latent state remains unclear. Here, we applied high-resolution DNA barcode tracking to a mouse model that recapitulated the metastatic dormancy of head and neck squamous cell carcinoma (HNSCC). We found that clones abundantly circulated...

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PMID: 33731803
DOI: 10.1038/s41598-021-85743-z

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