Article
Beyond DNA repair and chromosome instability-Fanconi anaemia as a cellular senescence-associated syndrome.
Cell death and differentiation - 1 Apr 2021
Helbling-Leclerc Anne, Garcin Cécile, Rosselli Filippo
Abstract excerpt
Fanconi anaemia (FA) is the most frequent inherited bone marrow failure syndrome, due to mutations in genes encoding proteins involved in replication fork protection, DNA interstrand crosslink repair and replication rescue through inducing double-strand break repair and homologous recombination. Clinically, FA is characterised by aplastic anaemia, congenital defects and cancer predisposition. In in vitro studies,...
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