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Towards prevention of aneuploidy-associated cellular senescence and aging: more questions than answers?

1 Jul 2023

Abstract excerpt

The aim of this review is to discuss how aneuploidy contributes to the aging process, and to identify plausible strategies for its prevention. After an overview of mechanisms leading to aneuploidy and the major features of cellular senescence, we discuss the link between (i) aneuploidy and cellular senescence; (ii) aneuploidy and aging; and (iii) cellular senescence and aging. We also consider (i) interactions...

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PMID: 37866738
DOI: 10.1016/j.mrrev.2023.108474

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