Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes

Abstract excerpt

As average lifespan and elderly people prevalence in the western world population is gradually increasing, the incidence of age-related diseases such as cancer, heart diseases, diabetes, and dementia are increasing, bearing social and economic consequences globally. Understanding the molecular basis of aging-related processes can help extend the organism's health-span, i.e. the life period in which the organism...