Article
Impact of cellular senescence signature on ageing research.
Ageing research reviews - 1 Jan 2011
Sikora Ewa, Arendt Thomas, Bennett Martin, Narita Masashi
Abstract excerpt
Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism. However, due to the associated secretory phenotype senescence can also contribute to cancer and possibly other age-related diseases, such as obesity, diabetes, atherosclerosis and Alzheimer's disease. There are two major mechanisms of cellular senescence; replicative senescence depends on telomere...
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