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Article

Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration.

Cell death & disease - 15 Mar 2021

Lin Yuli, Chen Yusheng, Feng Wenxue, Hua Rong, Zhang Junfeng, Huo Yanmiao, Jiang Hong, Yin Bo, Yang Xuguang

Abstract excerpt

Chronic pancreatitis (CP) is characterized by a wide range of irreversible fibro-inflammatory diseases with largely ambiguous pathogenesis. Although neddylation pathway has been implicated in regulating immune responses, whether the dysregulation of neddylation is involved in the progression of CP and how neddylation regulates the inflammatory microenvironment of CP have not yet been reported. Here, we...

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Identifiers

PMID: 33723230
DOI: 10.1038/s41419-021-03549-3
PMCID: PMC7960984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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